Patients With Crohn’s Disease Have A Signifcantly Reduced Diversity Of Microflora Which Can Be Treated With FMT

A paper published in the British Medical Journal’s Gut magazine describes how DNA profiling has revealed that patients with Crohn’s disease have a significantly reduced diversity of microflora.

(Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach – C Manichanh, L Rigottier-Gois, E Bonnaud, K Gloux, E Pelletier, L Frangeul, R Nalin, C Jarrin, P Chardon, P Marteau, J Roca, J DoreGut 2006;55:205-211 doi:10.1136/gut.2005.073817)

DNA testing by 16S rRNA profiling has revealed that Crohn’s patients have significantly fewer of the species of a bacterial family called Firmicutes than a healthy norm.  Normal healthy gut flora showed diverse species and sub-species of both Bacteroidetes and Firmicutes (click on diagram below) which greatly outnumbered those found in the Crohn’s samples.

Once again, this indicates that reduced bacterial diversity is at the root of inflammatory bowel diseases. Some of the facultative (helpful) and commensal (friendly) bacteria are missing in the guts of diseased individuals.

How would you rectify this situation?    This demonstrates, yet again, the sound, biological sense behind Fecal Microbiota Transplant (FMT) from tested, healthy donors with a broad diversity of micro-flora which has been demonstrated in the DNA profiling of their gut flora, done as part of the donor screening.

Illustration courtesy of BioMed Central<%